Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL256624 | 0.79 | CYP3A4 (0.52) | CYP1A2CYP2C9QPCTALDH1A1HPGD | |
| SCHEMBL7007424 | 0.77 | CYP3A4 (0.69) | CYP1A2CYP2C9MAOAMAOBALDH1A1 | |
| SCHEMBL29993530 | 0.77 | CYP3A4 (0.50) | CYP1A2CYP2C9QPCTALDH1A1HPGD | |
| SCHEMBL7660151 | 0.76 | CYP1A2 (0.38) | CYP1A2CYP2C9QPCTALDH1A1HPGD | |
| SCHEMBL23277364 | 0.74 | MAOA (0.62) | MAOAMAOBALDH1A1HPGDCYP3A4 | |
| SCHEMBL3891569 | 0.74 | MAOA (0.62) | MAOAMAOBALDH1A1HPGDCYP3A4 | |
| SCHEMBL795030 | 0.74 | MAOA (0.62) | MAOAMAOBALDH1A1HPGDCYP3A4 | |
| SCHEMBL3891151 | 0.74 | MAOA (0.62) | MAOAMAOBALDH1A1HPGDCYP3A4 | |
| SCHEMBL7808697 | 0.71 | ALDH1A1 (0.54) | CYP1A2CYP2C9QPCTALDH1A1HPGD | |
| SCHEMBL7015795 | 0.71 | CYP1A2 (0.59) | CYP1A2CYP2C9QPCTMAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065209-B1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-05-02 | — | — | EP | disclosed |
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |
| EP-1065209-A1 | Metalloprotease inhibitors, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-03 | — | — | EP | disclosed |