Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5411898 | 0.72 | CRHR1 (0.72) | CRHR1 | |
| SCHEMBL785502 | 0.71 | HSD11B1 (0.46) | CRHR1 | |
| SCHEMBL4460206 | 0.70 | DPP4 (0.72) | — | |
| SCHEMBL10642190 | 0.69 | AHR (0.47) | CRHR1 | |
| SCHEMBL14529289 | 0.69 | HSD11B1 (0.41) | CRHR1 | |
| SCHEMBL12653943 | 0.68 | HSD11B1 (0.50) | CRHR1 | |
| SCHEMBL91621 | 0.68 | ALDH1A1 (0.52) | — | |
| SCHEMBL12871871 | 0.68 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL6100769 | 0.67 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL9566485 | 0.66 | HTR2B (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317450-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002022604-A1 | PYRAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2002-03-21 | — | — | WO | disclosed |