Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.37 |
| ▸ | CTSV | O60911 | 4/20 | 0.37 |
| ▸ | CTSK | P43235 | 4/20 | 0.37 |
| ▸ | CTSL | P07711 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016835 | 0.93 | CTSS (0.41) | CTSSCTSVCTSKCTSLDPP4 | |
| SCHEMBL7017633 | 0.83 | CTSS (0.40) | CTSSCTSVCTSKCTSLDPP4 | |
| SCHEMBL7023387 | 0.83 | CTSS (0.40) | CTSSCTSVCTSKCTSLDPP4 | |
| SCHEMBL7018439 | 0.83 | CTSS (0.40) | CTSSCTSVCTSKCTSLDPP4 | |
| SCHEMBL7016638 | 0.83 | CTSS (0.40) | CTSSCTSVCTSKCTSLDPP4 | |
| SCHEMBL7019334 | 0.81 | CTSS (0.40) | CTSSCTSVCTSKCTSL | |
| SCHEMBL7019497 | 0.80 | CTSS (0.40) | CTSSCTSVCTSKCTSL | |
| SCHEMBL6801202 | 0.78 | CTSK (0.37) | CTSSCTSVCTSKCTSL | |
| SCHEMBL5256719 | 0.78 | DPP4 (0.59) | DPP4 | |
| SCHEMBL7017077 | 0.78 | CTSS (0.38) | CTSSCTSVCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |