Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011555 | 0.93 | PDE5A (0.44) | MAPTHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7010973 | 0.90 | MAPT (0.44) | MAPTHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8171072 | 0.90 | ALDH1A1 (0.47) | MAPTHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7022055 | 0.89 | SMN1; SMN2 (0.49) | MAPTHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7019969 | 0.89 | MEN1 (0.49) | MAPTHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7016750 | 0.89 | CNR1 (0.46) | MAPTHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7020386 | 0.89 | MAPT (0.44) | MAPTHTTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7015004 | 0.88 | KMT2A (0.44) | HTTSMN1; SMN2KMT2ANPSR1ALDH1A1 | |
| SCHEMBL7018206 | 0.88 | KMT2A (0.40) | SMN1; SMN2KMT2ANPSR1ALDH1A1KDM4E | |
| SCHEMBL7016674 | 0.88 | PTPN12 (0.47) | MAPTHTTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |