Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015539 | 0.94 | SMN1; SMN2 (0.48) | SMN1; SMN2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL7017962 | 0.90 | LMNA (0.53) | SMN1; SMN2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL7014333 | 0.88 | HPGD (0.49) | SMN1; SMN2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL7008899 | 0.86 | SLC6A7 (0.52) | SMN1; SMN2CYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL7010368 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL7016083 | 0.85 | HPGD (0.47) | SMN1; SMN2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL7015657 | 0.85 | TP53 (0.52) | SMN1; SMN2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL7016908 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL7016066 | 0.84 | MEN1 (0.47) | SMN1; SMN2CYP3A4CYP2C9CYP2C19LMNA | |
| SCHEMBL7015131 | 0.84 | KDM4E (0.52) | SMN1; SMN2CYP2C9CYP2C19LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |