Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.37 |
| ▸ | CTSS | P25774 | 6/20 | 0.36 |
| ▸ | CTSV | O60911 | 4/20 | 0.35 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457969 | 0.78 | HDAC8 (0.44) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL6956963 | 0.77 | MMP1 (0.35) | — | |
| SCHEMBL4449833 | 0.76 | HDAC8 (0.48) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL4457715 | 0.74 | CTSS (0.45) | CTSKCTSSCTSVCTSL | |
| SCHEMBL5255403 | 0.73 | CTSS (0.44) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL5098324 | 0.72 | DPP4 (0.58) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL7019264 | 0.67 | CTSS (0.41) | CTSKCTSSCTSVCTSL | |
| SCHEMBL5256719 | 0.67 | DPP4 (0.59) | DPP4 | |
| SCHEMBL7100155 | 0.66 | CTSS (0.70) | CTSKCTSSCTSVCTSL | |
| SCHEMBL13677164 | 0.66 | CTSS (0.70) | CTSKCTSSCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |