Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | CTSV | O60911 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | ME2 | P23368 | 2/20 | 0.41 |
| ▸ | ME1 | P48163 | 2/20 | 0.41 |
| ▸ | ME3 | Q16798 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017635 | 0.89 | CTSS (0.41) | CTSSCTSVCTSLCTSKL3MBTL3 | |
| SCHEMBL7016644 | 0.89 | GFER (0.42) | CTSSCTSVCTSLCTSKME2 | |
| SCHEMBL7017081 | 0.84 | OPRK1 (0.41) | CTSSCTSVCTSLCTSK | |
| SCHEMBL7016835 | 0.80 | CTSS (0.41) | CTSSCTSVCTSLCTSKME3 | |
| SCHEMBL5098324 | 0.78 | DPP4 (0.58) | CTSSCTSVCTSLCTSK | |
| SCHEMBL13677233 | 0.77 | CTSS (0.54) | CTSSCTSVCTSLCTSK | |
| SCHEMBL5104927 | 0.77 | CTSS (0.54) | CTSSCTSVCTSLCTSK | |
| SCHEMBL4449120 | 0.77 | CTSS (0.54) | CTSSCTSVCTSLCTSK | |
| SCHEMBL7016869 | 0.77 | CTSS (0.43) | CTSSCTSVCTSLCTSKNAAA | |
| SCHEMBL7147742 | 0.76 | CTSS (0.40) | CTSSCTSVCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |