Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.71 |
| ▸ | GAK | O14976 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3321525 | 0.85 | ERBB2 (0.71) | ALKERBB2GAKEGFRHTT | |
| SCHEMBL1387165 | 0.84 | ERBB2 (1.00) | ALKERBB2GAKEGFRHTT | |
| Hydrochloric Acid SCHEMBL8812168 | 0.82 | ERBB2 (0.97) | ALKERBB2GAKEGFRHTT | |
| SCHEMBL7015701 | 0.82 | ALK (0.78) | ALKERBB2GAKEGFRRIPK2 | |
| SCHEMBL10000194 | 0.81 | ERBB2 (0.94) | ALKERBB2GAKEGFRHTT | |
| SCHEMBL8809979 | 0.79 | FGFR2 (0.72) | ERBB2GAKEGFRHTTFGFR2 | |
| SCHEMBL19633677 | 0.79 | ALK (0.67) | ALKERBB2GAKEGFRHTT | |
| SCHEMBL19633717 | 0.78 | ALK (0.81) | ALKGAKEGFR | |
| Hydrochloric Acid SCHEMBL8933873 | 0.78 | FGFR2 (0.70) | ERBB2GAKEGFRHTTFGFR2 | |
| SCHEMBL28133700 | 0.77 | ERBB2 (0.71) | ALKERBB2GAKEGFRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |