Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.49 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL7839376 | 0.94 | CHRNA7 (0.77) | CHRNA7OPRM1OPRK1OPRL1HTR2C | |
| Iodide SCHEMBL7847003 | 0.86 | CHRNA7 (0.83) | CHRNA7OPRM1OPRK1OPRL1HTR2C | |
| SCHEMBL20137193 | 0.81 | CHRNA7 (0.80) | CHRNA7OPRM1OPRK1OPRL1HTR2C | |
| SCHEMBL2811534 | 0.81 | CHRNA7 (1.00) | CHRNA7OPRM1OPRK1OPRL1 | |
| SCHEMBL5899579 | 0.81 | CHRNA7 (0.80) | CHRNA7OPRM1OPRK1OPRL1HTR2C | |
| SCHEMBL9737757 | 0.80 | CHRNA7 (0.77) | CHRNA7OPRM1OPRK1OPRL1HTR2C | |
| Hydrochloric Acid SCHEMBL7509300 | 0.80 | CHRNA7 (0.96) | CHRNA7OPRM1OPRK1OPRL1 | |
| Iodide SCHEMBL7016592 | 0.80 | CHRNA7 (0.96) | CHRNA7OPRM1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL6421624 | 0.79 | CHRNA7 (0.75) | CHRNA7OPRM1OPRK1OPRL1HTR2C | |
| SCHEMBL14239889 | 0.77 | CHRNA7 (0.90) | CHRNA7OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |