SCHEMBL7014473 — predicted protein targets

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	TSHR	P16473	1/20	0.33

▸	CYP1A2	P05177	1/20	0.33

▸	MEN1	O00255	1/20	0.30

▸	ALDH1A1	P00352	1/20	0.30

▸	POLB	P06746	1/20	0.30

▸	PKM	P14618	1/20	0.30

▸	KMT2A	Q03164	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7014468	1.00	TSHR (0.33)	TSHRCYP1A2MEN1ALDH1A1POLB
SCHEMBL7014984	0.87	TSHR (0.32)	TSHRCYP1A2ALDH1A1
SCHEMBL7014980	0.87	TSHR (0.32)	TSHRCYP1A2ALDH1A1
SCHEMBL7017374	0.77	CYP1A2 (0.60)	TSHRCYP1A2MEN1ALDH1A1KMT2A
SCHEMBL7015733	0.73	FEN1 (0.50)	CYP1A2ALDH1A1POLBPKMKMT2A
SCHEMBL7015737	0.73	FEN1 (0.50)	CYP1A2ALDH1A1POLBPKMKMT2A
SCHEMBL7019436	0.72	TSHR (0.35)	TSHRCYP1A2MEN1ALDH1A1POLB
SCHEMBL7019442	0.72	TSHR (0.35)	TSHRCYP1A2MEN1ALDH1A1POLB
SCHEMBL7015562	0.72	XDH (0.44)	ALDH1A1
SCHEMBL7019576	0.72	PDE4A (0.31)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1357114-A1	Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP)	IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE)	2003-10-29	—	—	EP	disclosed