Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7013991 | 0.99 | MTNR1B (0.42) | MTNR1BHTR1AHTR2AHTR7HTR6 | |
| SCHEMBL7006993 | 0.93 | ROCK2 (0.43) | MTNR1BROCK2CYP3A4RORCALDH1A1 | |
| SCHEMBL7012607 | 0.92 | TP53 (0.47) | MTNR1BRORCLMNAMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL7013753 | 0.92 | ROCK2 (0.42) | MTNR1BROCK2CYP3A4RORCALDH1A1 | |
| SCHEMBL7008091 | 0.92 | RORC (0.40) | MTNR1BROCK2RORCDRD3ALDH1A1 | |
| SCHEMBL7007952 | 0.92 | RORC (0.42) | MTNR1BRORCDRD3 | |
| Hydrochloric Acid SCHEMBL7841212 | 0.92 | TP53 (0.46) | MTNR1BRORCLMNAMAPTMEN1 | |
| SCHEMBL7012754 | 0.89 | RORC (0.44) | ROCK2CYP3A4RORCCHRNA7MAPT | |
| Hydrochloric Acid SCHEMBL7009820 | 0.89 | RORC (0.44) | ROCK2CYP3A4RORCCHRNA7MAPT | |
| SCHEMBL7011281 | 0.86 | ROCK2 (0.44) | MTNR1BROCK2CYP3A4RORCCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | claimed |
| EP-1102769-B1 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2003-04-16 | — | — | EP | disclosed |
| EP-1102769-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008020-A2 | TRICYCLIC CARBOXAMIDES | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-17 | — | — | WO | disclosed |