Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014787 | 1.00 | TSHR (0.33) | TSHRALDH1A1HPGDKDM4EMAPK1 | |
| SCHEMBL7019442 | 0.86 | TSHR (0.35) | TSHRALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL7019436 | 0.86 | TSHR (0.35) | TSHRALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL7014980 | 0.74 | TSHR (0.32) | TSHRALDH1A1HPGDKDM4EMPO | |
| SCHEMBL7014984 | 0.74 | TSHR (0.32) | TSHRALDH1A1HPGDKDM4EMPO | |
| SCHEMBL7019417 | 0.73 | FEN1 (0.50) | ALDH1A1KDM4EHSD17B10POLBPKM | |
| SCHEMBL7019413 | 0.73 | FEN1 (0.50) | ALDH1A1KDM4EHSD17B10POLBPKM | |
| SCHEMBL7022632 | 0.72 | XDH (0.41) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7023095 | 0.72 | ADORA3 (0.32) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7022638 | 0.72 | XDH (0.41) | ALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |