Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440808 | 0.85 | NAPRT (0.72) | NAPRTDGAT1SMN1; SMN2GAARAB9A | |
| SCHEMBL2475597 | 0.82 | NAPRT (0.62) | NAPRTDGAT1SMN1; SMN2GAARAB9A | |
| SCHEMBL3383611 | 0.80 | NAPRT (0.66) | NAPRTALDH1A1DGAT1SMN1; SMN2GAA | |
| SCHEMBL31473447 | 0.80 | NAPRT (0.66) | NAPRTALDH1A1DGAT1SMN1; SMN2GAA | |
| SCHEMBL6852409 | 0.79 | ALDH1A1 (0.68) | ALDH1A1HSD17B10LMNAEGFR | |
| SCHEMBL4467915 | 0.79 | NPC1 (0.62) | NAPRTALDH1A1DGAT1SMN1; SMN2GAA | |
| SCHEMBL17676098 | 0.79 | RAB9A (0.64) | NAPRTALDH1A1DGAT1SMN1; SMN2GAA | |
| SCHEMBL5305773 | 0.79 | NAPRT (0.58) | NAPRTDGAT1SMN1; SMN2GAARAB9A | |
| SCHEMBL29457431 | 0.79 | NPC1 (0.62) | NAPRTALDH1A1DGAT1SMN1; SMN2GAA | |
| SCHEMBL3565290 | 0.77 | HSD17B10 (0.70) | ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |