SCHEMBL7015152

SCHEMBL7015152

CC(C)(C)[Si](OCc1cc(N)ccc1Cl)(c1ccccc1)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.37
BCL2L1 Q07817 1/20 0.34
IDO1 P14902 2/20 0.34
HTR2A P28223 1/20 0.33
SLC6A4 P31645 1/20 0.33
CYP3A4 P08684 1/20 0.33
TSHR P16473 1/20 0.33
ALDH1A1 P00352 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
GAA P10253 1/20 0.32
ALOX15 P16050 1/20 0.32
HTT P42858 1/20 0.32
SLC16A3 O15427 4/20 0.32
SLC16A1 P53985 4/20 0.32
MCTS1 Q9ULC4 4/20 0.32
EPHX2 P34913 1/20 0.32
NR1H4 Q96RI1 1/20 0.32
SMYD2 Q9NRG4 2/20 0.31
PLA2G7 Q13093 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22559528 0.89 EPHX2 (0.39) SYKIDO1CYP3A4TSHRALDH1A1
SCHEMBL147397 0.84 LMNA (0.36) HTR2ASLC6A4ALDH1A1GAAHTT
SCHEMBL28677856 0.81 SMYD2 (0.31) TSHRGAAHTTSMYD2MAPT
SCHEMBL7013760 0.80 MRGPRX4 (0.34) HTTSLC16A3SLC16A1MCTS1MAPT
SCHEMBL18149538 0.79 CYP3A4 (0.37) SYKBCL2L1IDO1HTR2ASLC6A4
SCHEMBL34474697 0.78 MAPT (0.44) CYP3A4ALDH1A1TDP1GAAALOX15
SCHEMBL22690251 0.77 RIPK1 (0.33) CYP3A4TSHRALDH1A1HTTSMN1; SMN2
SCHEMBL222047 0.77 MAOB (0.43) IDO1GAAMAPTSMN1; SMN2
SCHEMBL2474304 0.77 CYP3A4 (0.36) CYP3A4ALDH1A1TDP1SMYD2MAPT
SCHEMBL6641986 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0861243-B1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 2003-11-12 EP disclosed
US-6344462-B1 Heterocyclic compounds as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-02-05 US disclosed
US-6127389-A TREATMENT OF HYPERTENSION, RENAL DISEASES, HEART FAILURE, HYPERTENSION, MENIERE'S DISEASE, PERIPHERAL AND CEREBRAL CIRCULATORY DISORDERS, CLIMACTERIC DISTURBANCE, RETINOCHOROIDAL CIRCULATORY DISORDERS, MYOCARDIAL ISCHEMIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-10-03 US disclosed
US-6100284-A ANTIALLERGENS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-08-08 US disclosed
US-6015818-A TREATING KIDNEY, BRAIN, AND CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-01-18 US disclosed
US-6008229-A TREATING ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0879233-A1 CHINOLINE AND BENZIMIDAZOLE DERIVATIVES AS BRADYKININ AGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-25 EP disclosed
EP-0861243-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-09-02 EP disclosed
WO-1997028153-A1 CHINOLINE AND BENZIMIDAZOLE DERIVATIVES AS BRADYKININ AGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-08-07 WO disclosed
WO-1997011069-A1 HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-03-27 WO disclosed