SCHEMBL7015170

SCHEMBL7015170

CS(=O)(=O)n1c2ccccc2oc(=O)oc2ccccc21

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
GAA P10253 2/20 0.51
HPGD P15428 4/20 0.42
TSHR P16473 2/20 0.42
MAPK1 P28482 2/20 0.42
USP2 O75604 1/20 0.42
NPSR1 Q6W5P4 2/20 0.39
MIF P14174 1/20 0.38
IDO1 P14902 2/20 0.37
LMNA P02545 2/20 0.37
AGTR1 P30556 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GLA P06280 1/20 0.36
CYP3A4 P08684 1/20 0.36
MAPT P10636 1/20 0.36
PGAM1 P18669 1/20 0.36
MAOA P21397 1/20 0.36
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14027358 0.85 ALDH1A1 (0.64) ALDH1A1SMN1; SMN2GAAHPGDTSHR
SCHEMBL7006570 0.79 ALDH1A1 (0.60) ALDH1A1SMN1; SMN2GAAHPGDTSHR
SCHEMBL11863183 0.73 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2GAAHPGDTSHR
SCHEMBL11863188 0.73 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2GAAHPGDTSHR
SCHEMBL9261893 0.72 POLB (0.44) ALDH1A1SMN1; SMN2GAAHPGDTSHR
SCHEMBL14524222 0.71 AGTR1 (0.54) ALDH1A1AGTR1KDM4EL3MBTL1
SCHEMBL3227094 0.70 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2GAAHPGDTSHR
SCHEMBL339615 0.70 MAOA (0.57) ALDH1A1SMN1; SMN2GAAHPGDTSHR
SCHEMBL30205812 0.70 MAOA (0.57) ALDH1A1SMN1; SMN2GAAHPGDTSHR
SCHEMBL1389047 0.68 HPGD (0.43) ALDH1A1SMN1; SMN2GAAHPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1163239-B1 MODIFIED AMINO-ACID AMIDES AS CGRP ANTAGONISTS BOEHRINGER INGELHEIM PHARMA (DE) 2003-05-28 EP disclosed
EP-1163239-A1 MODIFIED AMINO-ACID AMIDES AS CGRP ANTAGONISTS Boehringer Ingelheim Pharma KG (DE) 2001-12-19 EP disclosed
US-6313097-B1 TREATMENT OR PROPHYLAXIS OF MIGRAINE OR CLUSTER HEADACHES, NON-INSULIN-DEPENDENT DIABETES MELLITUS, INFLAMMATION, ALLERGIC RHINITIS, ASTHMA, MORPHINE TOLERANCE, MENOPAUSAL HOT FLASHES, DISEASES CHARACTERIZED BY EXCESSIVE VASODILATATION BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-11-06 US disclosed
WO-2000055154-A1 MODIFIED AMINO-ACID AMIDES AS CGRP ANTAGONISTS BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-09-21 WO disclosed