Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | UBE2N | P61088 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013136 | 0.94 | LMNA (0.65) | LMNAMAPK1POLBHIF1APDE4A | |
| SCHEMBL7015993 | 0.91 | LMNA (0.66) | LMNAMAPK1POLBHIF1APDE4A | |
| SCHEMBL7018390 | 0.91 | LMNA (0.69) | LMNAMAPK1POLBHIF1AMAPT | |
| SCHEMBL7012058 | 0.88 | LMNA (0.65) | LMNAMAPK1POLBHIF1AADORA2B | |
| SCHEMBL7011108 | 0.86 | LMNA (0.84) | LMNAMAPK1POLBMAPTADORA2B | |
| SCHEMBL30149464 | 0.85 | LMNA (0.70) | LMNAMAPK1POLBHIF1APDE4A | |
| Hydrochloric Acid SCHEMBL7019827 | 0.85 | LMNA (0.82) | LMNAMAPK1POLBMAPTADORA2B | |
| SCHEMBL8642085 | 0.84 | LMNA (0.43) | LMNAMAPK1PDE4AMAPTESR1 | |
| SCHEMBL7015123 | 0.82 | LMNA (0.66) | LMNAMAPK1POLBHIF1AADORA2B | |
| SCHEMBL7015950 | 0.82 | MAPK1 (0.56) | LMNAMAPK1POLBHIF1APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |