Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.54 |
| ▸ | HTR7 | P34969 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.44 |
| ▸ | HTR1B | P28222 | 5/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007932 | 0.86 | HTR1A (0.60) | HTR1AHTR7HPGDPOLBADRA1D | |
| SCHEMBL7011681 | 0.85 | HPGD (0.48) | HTR1AHTR7HPGDPOLBCYP3A4 | |
| Hydrochloric Acid SCHEMBL7722346 | 0.84 | HPGD (0.48) | HTR1AHTR7HPGDPOLBCYP3A4 | |
| SCHEMBL7015088 | 0.83 | HTR1A (0.52) | HTR1AHTR7HPGDPOLBCYP3A4 | |
| SCHEMBL7016146 | 0.83 | HTR1A (0.51) | HTR1AHTR7HPGDPOLBADRA1D | |
| SCHEMBL7012057 | 0.83 | HTR1A (0.61) | HTR1AHTR7HPGDPOLBADRA1D | |
| SCHEMBL7012098 | 0.82 | RXFP1 (0.54) | HTR1AHTR7HPGDPOLBADRA1D | |
| SCHEMBL7014563 | 0.82 | HTR1A (0.53) | HTR1AHTR7HPGDPOLBADRA1D | |
| SCHEMBL7009792 | 0.81 | HTR1A (0.56) | HTR1AHTR7CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7014231 | 0.80 | HTR1A (0.63) | HTR1AHTR7ADRA1DHTR1BADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988306-B1 | 3-SUBSTITUTED 3,4 DIHYDRO-THIENO 2, 3-D]PYRIMIDINE DERIVATIVES AND PRODUCTION AND USE OF THE SAME | ABBOTT GMBH & CO KG (DE) | 2003-07-09 | — | — | EP | disclosed |
| US-6387912-B1 | STROKE THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6159962-A | 3-substituted 3,4-dihydro-thieno[2,3-D]pyrimidine derivatives and production and use of the same | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-12 | — | — | US | disclosed |