Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.51 |
| ▸ | HTR1B | P28222 | 5/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012057 | 0.90 | HTR1A (0.61) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7014563 | 0.87 | HTR1A (0.53) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7007932 | 0.85 | HTR1A (0.60) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7009792 | 0.83 | HTR1A (0.56) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7015282 | 0.83 | HTR1A (0.54) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7013844 | 0.83 | HTR1A (0.62) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7012872 | 0.83 | HTR1A (0.62) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7014231 | 0.83 | HTR1A (0.63) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7011681 | 0.83 | HPGD (0.48) | HTR1AADRA1DHTR1BADRA1AADRA1B | |
| SCHEMBL7011215 | 0.83 | HTR1A (0.51) | HTR1AADRA1DHTR1BADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0988306-B1 | 3-SUBSTITUTED 3,4 DIHYDRO-THIENO 2, 3-D]PYRIMIDINE DERIVATIVES AND PRODUCTION AND USE OF THE SAME | ABBOTT GMBH & CO KG (DE) | 2003-07-09 | — | — | EP | disclosed |
| US-6387912-B1 | STROKE THERAPY | BASF AKTIENGESELLSCHAFT (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6159962-A | 3-substituted 3,4-dihydro-thieno[2,3-D]pyrimidine derivatives and production and use of the same | BASF AKTIENGESELLSCHAFT (DE) | 2000-12-12 | — | — | US | disclosed |