Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017988 | 0.90 | MEN1 (0.61) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL7016008 | 0.89 | MEN1 (0.47) | MEN1KMT2AGPBAR1DRD2HDAC3 | |
| SCHEMBL7014540 | 0.88 | DRD2 (0.52) | MEN1KMT2ADRD2HDAC3HDAC4 | |
| SCHEMBL7017497 | 0.86 | TDP1 (0.52) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL7011506 | 0.80 | MEN1 (0.55) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL7014118 | 0.80 | MEN1 (0.46) | MEN1KMT2ADRD2HDAC3HDAC4 | |
| SCHEMBL7011335 | 0.78 | MEN1 (0.46) | MEN1KMT2AHDAC3HDAC4HDAC1 | |
| SCHEMBL7015657 | 0.78 | TP53 (0.52) | MEN1KMT2ATP53TDP1ALDH1A1 | |
| SCHEMBL7012515 | 0.78 | NLRP3 (0.43) | MEN1KMT2AGPBAR1DRD2HDAC3 | |
| SCHEMBL7017586 | 0.77 | MEN1 (0.57) | MEN1KMT2AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |