Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 17/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012215 | 0.86 | AGTR1 (0.53) | AGTR1AGTR2KDM4EMEN1MLNR | |
| SCHEMBL7015437 | 0.84 | AGTR1 (0.48) | AGTR1AGTR2AGT | |
| SCHEMBL7012415 | 0.82 | AGT (0.43) | AGTR1AGTR2AGT | |
| SCHEMBL2477228 | 0.81 | AGTR2 (0.71) | AGTR1AGTR2KDM4EMEN1MLNR | |
| SCHEMBL9007006 | 0.78 | AGTR1 (0.65) | AGTR1AGTR2KDM4EMEN1MLNR | |
| SCHEMBL9596100 | 0.77 | AGTR1 (0.62) | AGTR1AGTR2KDM4EMEN1MLNR | |
| SCHEMBL12991725 | 0.75 | AGT (0.51) | AGTR1AGTR2KDM4EMEN1MLNR | |
| SCHEMBL8242965 | 0.74 | AGTR1 (0.52) | AGTR1AGTR2KDM4EMEN1MLNR | |
| SCHEMBL28402948 | 0.73 | PPARG (0.57) | AGTR1AGTR2KDM4EMEN1MLNR | |
| SCHEMBL9596166 | 0.73 | AGTR1 (0.59) | AGTR1AGTR2KDM4EMEN1MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1327631-A2 | Fused heterocyclic compounds, their production and use as angiotensin II antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-07-16 | — | — | EP | disclosed |
| EP-0518033-B1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-07-02 | — | — | EP | disclosed |
| US-5389641-A | Fused heterocyclic compounds, having angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0518033-A1 | Fused heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-16 | — | — | EP | disclosed |