Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.53 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30592138 | 0.88 | MMP13 (0.60) | MMP13KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23521923 | 0.88 | MMP13 (0.60) | MMP13KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL18715381 | 0.84 | MMP13 (0.71) | MMP13KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL14284368 | 0.82 | MMP13 (0.60) | MMP13KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29328528 | 0.82 | MMP13 (0.60) | MMP13KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL16126516 | 0.82 | POLB (0.55) | MMP13ALDH1A1HPGDPOLBRXFP1 | |
| SCHEMBL922567 | 0.81 | HPGD (0.68) | MMP13KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30780038 | 0.81 | GAA (0.62) | MMP13KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL14724810 | 0.81 | GAA (0.62) | MMP13KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8358840 | 0.81 | MMP13 (1.00) | MMP13KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |