Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445669 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1MEN1GALR3HTT | |
| SCHEMBL447975 | 0.91 | CYP19A1 (0.46) | CYP19A1CYP11B1CYP11B2SMN1; SMN2L3MBTL1 | |
| SCHEMBL429604 | 0.74 | ALDH1A1 (0.53) | CYP19A1SMN1; SMN2MEN1KMT2APDE4B | |
| SCHEMBL2650165 | 0.72 | MAPK14 (0.52) | CYP19A1CYP11B1CYP11B2SMN1; SMN2L3MBTL1 | |
| SCHEMBL429611 | 0.72 | ALDH1A1 (0.55) | CYP19A1CYP11B1CYP11B2SMN1; SMN2L3MBTL1 | |
| SCHEMBL28506919 | 0.71 | ALDH1A1 (0.46) | MEN1KMT2ATDP1MAPTRAB9A | |
| SCHEMBL30586132 | 0.70 | CA2 (0.46) | CYP19A1CYP11B1CYP11B2MEN1KMT2A | |
| Iodide SCHEMBL28504446 | 0.70 | ALDH1A1 (0.45) | MEN1KMT2ATDP1MAPTRAB9A | |
| SCHEMBL14809788 | 0.69 | CYP19A1 (0.52) | CYP19A1CYP11B1CYP11B2SMN1; SMN2L3MBTL1 | |
| Iodide SCHEMBL8102721 | 0.69 | L3MBTL1 (0.45) | L3MBTL1KMT2AMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358161-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002055501-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMGEN INC (US) | 2002-07-18 | — | — | WO | disclosed |