SCHEMBL7016263

SCHEMBL7016263

CCCCCCC(C(=O)N1CC(Oc2ccc(C(=O)O)cc2)C[C@H]1C(=O)O)n1cnc2cc(-c3ccccc3-c3nnn[nH]3)ccc21

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PLA2G4A P47712 1/20 0.31
PTPN11 Q06124 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7016267 1.00 PLA2G4A (0.31) PLA2G4APTPN11
SCHEMBL7024956 0.94 SLC33A1 (0.31)
SCHEMBL7021775 0.94 KDR (0.30)
SCHEMBL7017568 0.94 KDR (0.30)
SCHEMBL8913862 0.93 MCL1 (0.32)
SCHEMBL7017422 0.93 MCL1 (0.32)
SCHEMBL8912763 0.93 HDAC3 (0.30)
SCHEMBL7021733 0.92 MCL1 (0.32)
SCHEMBL7021725 0.92 MCL1 (0.32)
SCHEMBL8911508 0.89 GYS1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0574174-B1 Angiotensin II antagonists LILLY CO ELI (US) 2003-08-13 EP disclosed
US-5569768-A USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY ELI LILLY AND COMPANY (US) 1996-10-29 US disclosed
EP-0574174-A2 Angiotensin II antagonists ELI LILLY AND COMPANY (US) 1993-12-15 EP disclosed