Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7599773 | 0.81 | HCAR2 (0.55) | HCAR2GAAALDH1A1TSHRATM | |
| SCHEMBL7586466 | 0.81 | HCAR2 (0.55) | HCAR2GAAALDH1A1TSHRATM | |
| SCHEMBL19987653 | 0.80 | L3MBTL1 (0.36) | SLC6A3HPGDL3MBTL1GAAPOLB | |
| SCHEMBL8055810 | 0.79 | SLC6A3 (0.40) | SLC6A3HPGDL3MBTL1GAAPOLB | |
| Fumaric Acid SCHEMBL7016387 | 0.76 | GABRP (0.38) | SLC6A3HPGDL3MBTL1GAAPOLB | |
| Fumaric Acid SCHEMBL7016383 | 0.76 | GABRP (0.38) | SLC6A3HPGDL3MBTL1GAAPOLB | |
| Fumaric Acid SCHEMBL7016389 | 0.76 | GABRP (0.38) | SLC6A3HPGDL3MBTL1GAAPOLB | |
| Vinyl Ether SCHEMBL28222295 | 0.75 | L3MBTL1 (0.33) | SLC6A3HPGDL3MBTL1GAAPOLB | |
| SCHEMBL6023045 | 0.74 | HCAR2 (0.60) | HCAR2GAAPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL27556238 | 0.74 | HCAR2 (0.60) | HCAR2GAAPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |