Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.44 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018995 | 0.80 | KDM5B (0.35) | KDM5BSMN1; SMN2BRD4 | |
| SCHEMBL7017850 | 0.74 | KDM5B (0.59) | KDM5BKDM5ALMNASMN1; SMN2 | |
| SCHEMBL19933292 | 0.74 | KDM5B (0.48) | KDM5BKDM5ALMNASMN1; SMN2 | |
| SCHEMBL24097994 | 0.70 | BRD4 (0.33) | BRD4 | |
| SCHEMBL19779666 | 0.70 | KDM5B (0.43) | KDM5BKDM5ALMNASMN1; SMN2 | |
| SCHEMBL19933352 | 0.67 | ADORA3 (0.51) | KDM5BKDM5ALMNASMN1; SMN2 | |
| SCHEMBL24222071 | 0.67 | — | — | |
| SCHEMBL23335815 | 0.66 | KDM4E (0.46) | KDM5BKDM5ALMNASMN1; SMN2BRD4 | |
| SCHEMBL23619312 | 0.64 | CDK1 (0.35) | — | |
| SCHEMBL24236934 | 0.64 | BRD9 (0.39) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |