Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TAF1 | P21675 | 1/20 | 0.30 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.30 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27311213 | 0.82 | TDP1 (0.49) | KDM5BBRD4RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL24097994 | 0.82 | BRD4 (0.33) | BRD4 | |
| SCHEMBL7017850 | 0.80 | KDM5B (0.59) | KDM5BRAB9ASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL7016511 | 0.80 | KDM5B (0.44) | KDM5BBRD4SMN1; SMN2 | |
| SCHEMBL31661272 | 0.73 | KMT2A (0.50) | RAB9ASMN1; SMN2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL19779493 | 0.70 | ADORA3 (0.39) | KDM5BRAB9ASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL23335815 | 0.70 | KDM4E (0.46) | KDM5BBRD4SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31661243 | 0.68 | SMN1; SMN2 (0.35) | BRD4SMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL24236934 | 0.68 | BRD9 (0.39) | BRD4KDM4EALDH1A1CYP1A2TAF1 | |
| SCHEMBL7015921 | 0.67 | KDM4E (0.54) | RAB9ASMN1; SMN2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |