Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 4/20 | 0.38 |
| ▸ | CTSV | O60911 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015308 | 0.95 | CTSK (0.46) | CTSKKMT2ACTSSCTSVCTSL | |
| SCHEMBL4457853 | 0.89 | PREP (0.47) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL7014847 | 0.87 | CTSK (0.44) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL4459112 | 0.87 | CTSS (0.50) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL4451291 | 0.86 | CTSK (0.56) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL7020885 | 0.86 | CTSK (0.43) | CTSKKMT2ACTSSCTSVCTSL | |
| SCHEMBL4459438 | 0.85 | CTSK (0.48) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL7014652 | 0.85 | CTSK (0.44) | CTSKCTSSCTSVCTSLDPP4 | |
| SCHEMBL4457938 | 0.85 | CTSS (0.47) | CTSKCTSSCTSVCTSLNPC1 | |
| SCHEMBL4451932 | 0.84 | CTSK (0.47) | CTSKCTSSCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |