SCHEMBL7016642

SCHEMBL7016642

N#Cc1ccc(Oc2ncc(SCCC=C(F)F)s2)cc1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.33
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
PDE10A Q9Y233 1/20 0.32
MMP2 P08253 4/20 0.32
MMP3 P08254 2/20 0.32
HSD17B10 Q99714 1/20 0.32
ICAM1 P05362 2/20 0.31
SELE P16581 2/20 0.31
VCAM1 P19320 2/20 0.31
CCNC P24863 1/20 0.31
CDK8 P49336 1/20 0.31
ALK Q9UM73 1/20 0.31
PARP15 Q460N3 1/20 0.31
PARP10 Q53GL7 1/20 0.31
PARP2 Q9UGN5 1/20 0.31
SCN9A Q15858 3/20 0.31
ACACB O00763 2/20 0.31
ACACA Q13085 1/20 0.31
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7020420 0.71 KDM4E (0.35) CYP19A1KDM4EMEN1MAPTKMT2A
SCHEMBL7021827 0.68
SCHEMBL27368484 0.67 CYP11B1 (0.47) CYP19A1CYP11B1CYP11B2ICAM1SELE
SCHEMBL27368610 0.67 CYP19A1 (0.44) CYP19A1CYP11B1CYP11B2ICAM1SELE
SCHEMBL9182491 0.64 PPARA (0.49) HSD17B10MEN1LMNAPOLBMAPT
SCHEMBL7023535 0.63
SCHEMBL8752031 0.62 ALDH1A1 (0.31) POLB
SCHEMBL7023733 0.60 RAB9A (0.31) MEN1POLBRAB9AKMT2A
SCHEMBL7028008 0.60
SCHEMBL9188516 0.60 DDAH1 (0.39) LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749433-B1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY SYNGENTA LTD (GB) 2003-05-07 EP disclosed
US-5952359-A NEMATICIDES, INSECTICIDES AND MITICIDES; 1,1-DIFLUORO-3-(THIAZOLYL OR ISOTHIAZOYL-THIO (OR SULFINYL OR SULFONYL)-PROP-1-ENE DERIVATIVES ZENECA LIMITED (GB) 1999-09-14 US disclosed
US-5912243-A NOVEL COMPOUNDS FOR CONTROLLING NEMATODES, INSECT OR ACARID PESTS ZENECA LIMITED (GB) 1999-06-15 US disclosed
US-5705516-A NEMATOCIDES, INSECTICIDES, ACARICIDES ZENECA LIMITED (GB) 1998-01-06 US disclosed
EP-0749433-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1996-12-27 EP disclosed
WO-1995024403-A1 (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY ZENECA LIMITED (GB) 1995-09-14 WO disclosed