Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 12/20 | 0.46 |
| ▸ | CASR | P41180 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923470 | 0.82 | PIK3CD (0.50) | ELANECASRPIK3CDPARP1LMNA | |
| SCHEMBL7011912 | 0.80 | ELANE (0.46) | ELANECASRPIK3CDPARP1 | |
| SCHEMBL9670265 | 0.76 | KDM4E (0.60) | LMNAGAAKDM4EALDH1A1HPGD | |
| SCHEMBL9670318 | 0.75 | PIK3CD (0.49) | ELANECASRPIK3CDPARP1LMNA | |
| SCHEMBL28451245 | 0.72 | PIK3CD (0.50) | ELANECASRPIK3CDPARP1LMNA | |
| SCHEMBL20081332 | 0.71 | NPC1 (0.62) | CASRPIK3CDLMNAGAAKDM4E | |
| SCHEMBL7014708 | 0.69 | ELANE (0.49) | ELANECASRPIK3CDPARP1LMNA | |
| SCHEMBL1129587 | 0.69 | PIK3CG (0.51) | ELANEPIK3CDLMNAKDM4EALDH1A1 | |
| SCHEMBL16796581 | 0.69 | TLR8 (0.55) | CASRLMNAGAAKDM4EALDH1A1 | |
| SCHEMBL13804449 | 0.69 | TRPA1 (0.51) | ELANEPARP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-5753664-A | ANTITUMOR AGENTS, PYRIMIDONES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |