Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24340312 | 0.87 | ALDH1A1 (0.51) | KDM4EMAPK1LMNAGAAMEN1 | |
| SCHEMBL10739963 | 0.84 | ALDH1A1 (0.60) | KDM4ELMNAGAAMEN1KMT2A | |
| SCHEMBL9670541 | 0.83 | ALDH1A1 (0.68) | KDM4EMAPK1RAB9ALMNAGAA | |
| SCHEMBL14010912 | 0.82 | ALDH1A1 (0.66) | KDM4ERAB9ALMNAGAAMEN1 | |
| SCHEMBL8347824 | 0.81 | MEN1 (0.68) | KDM4EMAPK1RAB9ALMNAGAA | |
| SCHEMBL14363850 | 0.80 | KDM4E (0.60) | KDM4EMAPK1RAB9ALMNAGAA | |
| SCHEMBL2994370 | 0.80 | KDM4E (0.60) | KDM4EMAPK1RAB9ALMNAGAA | |
| SCHEMBL9671285 | 0.80 | MEN1 (0.69) | KDM4ERAB9ALMNAGAAMEN1 | |
| SCHEMBL9724531 | 0.80 | TDP1 (0.59) | KDM4EMAPK1LMNAGAAMEN1 | |
| SCHEMBL31621465 | 0.80 | TDP1 (0.59) | KDM4EMAPK1LMNAGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276825-B1 | 4 (3H)-QUINAZOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-09-09 | — | — | EP | disclosed |
| EP-0276826-B1 | 2-ALKYLSULFINYL-4 (3H)-QUINAZOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-5008266-A | Antiulcer agent | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1991-04-16 | — | — | US | disclosed |
| US-4861780-A | 4(3H)-quinazolinone derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1989-08-29 | — | — | US | disclosed |
| US-4833144-A | ANTIULCER AGENTS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1989-05-23 | — | — | US | disclosed |
| EP-0276826-A1 | 2-Alkylsulfinyl-4 (3H)-quinazolinone derivatives, processes for their preparation and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1988-08-03 | — | — | EP | disclosed |
| EP-0276825-A1 | 4 (3H)-Quinazolinone derivatives, processes for their preparation and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1988-08-03 | — | — | EP | disclosed |