Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.43 |
| ▸ | CTSV | O60911 | 4/20 | 0.43 |
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7147742 | 0.82 | CTSS (0.40) | CTSSCTSVCTSKCTSL | |
| SCHEMBL7011896 | 0.82 | CTSS (0.40) | CTSSCTSVCTSKCTSL | |
| SCHEMBL4210699 | 0.77 | CTSS (0.49) | CTSSCTSVCTSKCTSL | |
| SCHEMBL2535456 | 0.77 | CTSS (0.49) | CTSSCTSVCTSKCTSL | |
| SCHEMBL7019264 | 0.77 | CTSS (0.41) | CTSSCTSVCTSKCTSLNAAA | |
| SCHEMBL7016866 | 0.76 | CTSS (0.42) | CTSSCTSVCTSKCTSL | |
| SCHEMBL7017635 | 0.76 | CTSS (0.41) | CTSSCTSVCTSKCTSL | |
| SCHEMBL7016644 | 0.76 | GFER (0.42) | CTSSCTSVCTSKCTSLTP53 | |
| SCHEMBL13677159 | 0.75 | CTSS (0.49) | CTSSCTSVCTSKCTSL | |
| SCHEMBL4449804 | 0.75 | CTSK (0.44) | CTSSCTSVCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |