Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710645 | 0.90 | DRD2 (0.54) | DRD2HTR6HTR1BHTR2A | |
| SCHEMBL7018674 | 0.87 | DRD2 (0.51) | DRD2HTR6HTR1BHTR2A | |
| SCHEMBL6642794 | 0.81 | DRD2 (0.43) | DRD2HTR6HTR1BHTR2ASLC6A4 | |
| SCHEMBL8182800 | 0.79 | DRD2 (0.41) | DRD2HTR6HTR1BHTR2ASLC6A4 | |
| SCHEMBL7019936 | 0.78 | HTR6 (0.41) | DRD2HTR6HTR2ASLC6A4 | |
| SCHEMBL7016982 | 0.78 | CHRM2 (0.43) | DRD2HTR6HTR1BHTR2ASLC6A4 | |
| SCHEMBL12128118 | 0.77 | APP (0.46) | DRD2HTR6HTR1B | |
| SCHEMBL27516823 | 0.76 | DRD2 (0.50) | DRD2HTR6HTR1BDRD4HTR2A | |
| SCHEMBL12127438 | 0.74 | DRD2 (0.39) | DRD2HTR6HTR1BSLC6A4 | |
| SCHEMBL12127481 | 0.74 | HTR1B (0.46) | DRD2HTR6HTR1BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089993-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2003-10-22 | — | — | EP | disclosed |
| EP-1089993-A1 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000487-A1 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |