Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 11/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 11/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011880 | 0.92 | CTNNB1 (0.45) | ESR1CTNNB1TCF7L2SLC26A6 | |
| SCHEMBL7018707 | 0.91 | ESR1 (0.44) | ESR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8185660 | 0.88 | MAPT (0.46) | ESR1CTNNB1TCF7L2EPHX2LMNA | |
| SCHEMBL7012518 | 0.88 | ESR1 (0.42) | ESR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7013520 | 0.88 | JAK2 (0.39) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7016510 | 0.87 | TP53 (0.40) | ESR1PDE5ACTNNB1TCF7L2 | |
| SCHEMBL7012439 | 0.86 | ALDH1A1 (0.43) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7013347 | 0.86 | PDE4A (0.42) | ESR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020092 | 0.86 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7018914 | 0.85 | PDE5A (0.46) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |