Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 8/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8917481 | 0.84 | DRD3 (0.54) | DRD3HTTKDM4ETSHRDRD2 | |
| SCHEMBL30100998 | 0.77 | CNR2 (0.53) | DRD3DRD2 | |
| SCHEMBL27569763 | 0.76 | DRD3 (0.48) | DRD3SMN1; SMN2KEAP1MEN1KMT2A | |
| SCHEMBL22653556 | 0.75 | KDM4E (0.42) | DRD3SMN1; SMN2KMT2AHTTKDM4E | |
| SCHEMBL7012360 | 0.75 | KEAP1 (0.39) | DRD3SMN1; SMN2KEAP1MEN1KMT2A | |
| SCHEMBL7013478 | 0.72 | DRD3 (0.46) | DRD3MEN1KMT2AKDM4EDRD2 | |
| SCHEMBL18110505 | 0.70 | SMN1; SMN2 (0.39) | SMN1; SMN2HTTKDM4ETSHRSLC6A4 | |
| SCHEMBL18110503 | 0.70 | BRD4 (0.41) | SMN1; SMN2MEN1KMT2AHTTKDM4E | |
| SCHEMBL8664503 | 0.70 | SMN1; SMN2 (0.49) | DRD3SMN1; SMN2KMT2AHTTKDM4E | |
| SCHEMBL21198991 | 0.69 | CNR2 (0.56) | DRD3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1419545-A | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors | WYETH CORP (US) | 2003-05-21 | — | — | CN | disclosed |
| EP-1268431-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072711-A1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-10-04 | — | — | WO | disclosed |