Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.38 |
| ▸ | GRK2 | P25098 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 2/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 1/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017087 | 0.90 | AAK1 (0.40) | AAK1GRK2PLK1PLK3BRD4 | |
| SCHEMBL7018800 | 0.80 | MAPT (0.35) | KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7019257 | 0.80 | MAPT (0.55) | LCKKDM4EALDH1A1QPCTQPCTL | |
| SCHEMBL7475809 | 0.76 | TDP1 (0.53) | LMNA | |
| SCHEMBL7017505 | 0.75 | PKM (0.53) | KDM4EALDH1A1LMNAHPGDBRD4 | |
| SCHEMBL2319934 | 0.74 | CYP11B1 (0.38) | LMNABRD4KDR | |
| SCHEMBL2358825 | 0.74 | CYP11B1 (0.38) | LMNABRD4KDR | |
| SCHEMBL7018562 | 0.73 | POLB (0.36) | LMNABRD4QPCTQPCTL | |
| SCHEMBL7016871 | 0.72 | MAPT (0.41) | LCKKDM4EALDH1A1BRD4QPCT | |
| SCHEMBL2541710 | 0.70 | POLB (0.37) | LMNABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |