Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.51 |
| ▸ | TEK | Q02763 | 9/20 | 0.51 |
| ▸ | MTOR | P42345 | 2/20 | 0.46 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5351772 | 0.91 | KDR (0.62) | KDRTEKBRAF | |
| SCHEMBL7015248 | 0.89 | KDR (0.54) | KDRTEKMTORBRAF | |
| SCHEMBL7017029 | 0.84 | KDR (0.65) | KDRTEKMTORBRAFCDK8 | |
| SCHEMBL7013996 | 0.84 | KDR (0.50) | KDRTEKMTORBRAF | |
| SCHEMBL7178082 | 0.83 | KDR (0.49) | KDRTEKMTORCDK8 | |
| SCHEMBL5360482 | 0.82 | KDR (0.66) | KDRTEKBRAF | |
| SCHEMBL7095826 | 0.82 | KDR (0.66) | KDRTEKMTORBRAF | |
| SCHEMBL7014470 | 0.81 | KDR (0.63) | KDRTEKMTOR | |
| SCHEMBL5342331 | 0.81 | KDR (0.63) | KDRTEKMTORCDK8 | |
| Hydrochloric Acid SCHEMBL5345130 | 0.81 | KDR (0.62) | KDRTEKMTORCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | claimed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | claimed |
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |