Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.59 |
| ▸ | NTRK2 | Q16620 | 14/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018569 | 0.83 | NTRK1 (0.52) | NTRK1NTRK2NPC1RAB9AMEN1 | |
| SCHEMBL855166 | 0.77 | MAPT (0.77) | NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL15685951 | 0.76 | PIN1 (0.65) | GAAMEN1KMT2AADRB1 | |
| SCHEMBL10035832 | 0.76 | HDAC6 (0.58) | NPC1GAARAB9ASMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL14736626 | 0.76 | MAPT (0.74) | NPC1GAARAB9ASMN1; SMN2 | |
| SCHEMBL13649430 | 0.73 | HDAC6 (0.61) | NPC1GAARAB9ASMN1; SMN2MEN1 | |
| SCHEMBL12880099 | 0.73 | MAPT (0.60) | NPC1GAARAB9ASMN1; SMN2MEN1 | |
| SCHEMBL14451618 | 0.72 | NPC1 (0.67) | NTRK1NTRK2NPC1GAARAB9A | |
| SCHEMBL17933571 | 0.72 | HDAC6 (0.72) | NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL20103468 | 0.71 | NTRK1 (1.00) | NTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972769-B1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMA CO LTD (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-6177454-B1 | ANTIDIABETIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| US-6048884-A | ANTIDIABETIC AGENTS; HYPOGLYCEMIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0972769-A1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |