Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 14/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 12/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018167 | 0.83 | NTRK1 (0.59) | NTRK1NTRK2KMT2AMEN1NPC1 | |
| SCHEMBL3874703 | 0.76 | RAB9A (0.57) | LMNAPOLBMAPTNPC1RAB9A | |
| SCHEMBL10035832 | 0.75 | HDAC6 (0.58) | KMT2AMEN1LMNAMAPTNPC1 | |
| SCHEMBL6622046 | 0.73 | KMT2A (0.55) | KMT2AMEN1NPSR1LMNAPOLB | |
| SCHEMBL12880099 | 0.72 | MAPT (0.60) | KMT2AMEN1NPSR1LMNAPOLB | |
| SCHEMBL17933571 | 0.71 | HDAC6 (0.72) | KMT2ALMNAPOLBMAPTNPC1 | |
| SCHEMBL15685951 | 0.71 | PIN1 (0.65) | KMT2AMEN1NPSR1LMNAPOLB | |
| SCHEMBL6622747 | 0.70 | CA1 (0.60) | KMT2AMEN1LMNAPOLBMAPT | |
| SCHEMBL13649430 | 0.70 | HDAC6 (0.61) | KMT2AMEN1LMNAPOLBMAPT | |
| SCHEMBL15685964 | 0.69 | ADRB1 (0.61) | KMT2AMEN1NPSR1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972769-B1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMA CO LTD (JP) | 2003-04-16 | — | — | EP | disclosed |
| US-6177454-B1 | ANTIDIABETIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| US-6048884-A | ANTIDIABETIC AGENTS; HYPOGLYCEMIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0972769-A1 | NOVEL AMIDE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |