Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014196 | 0.88 | MAPK1 (0.46) | LMNAMAPK1TP53TDP1HDAC1 | |
| SCHEMBL7018397 | 0.87 | MAPK1 (0.46) | LMNAMAPK1TP53TDP1HDAC1 | |
| SCHEMBL7015996 | 0.85 | HPGD (0.42) | LMNAMAPK1TP53TDP1HDAC1 | |
| SCHEMBL7015987 | 0.80 | TP53 (0.47) | BCL6LMNAMAPK1TP53TDP1 | |
| SCHEMBL7018715 | 0.78 | TP53 (0.48) | LMNAMAPK1TP53TDP1HDAC1 | |
| SCHEMBL7019303 | 0.76 | TP53 (0.46) | MAPK1TP53TDP1HDAC1HDAC6 | |
| SCHEMBL7014404 | 0.76 | TP53 (0.46) | MAPK1TP53TDP1HDAC1HDAC6 | |
| SCHEMBL7017888 | 0.75 | TP53 (0.47) | LMNAMAPK1TP53TDP1HDAC1 | |
| SCHEMBL7012844 | 0.74 | HDAC1 (0.47) | LMNATP53TDP1HDAC1HDAC6 | |
| SCHEMBL7014669 | 0.74 | HDAC1 (0.42) | LMNAMAPK1TP53TDP1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |