Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018264 | 0.85 | BCL6 (0.48) | POLBTP53TDP1LMNAMAPK1 | |
| SCHEMBL7018397 | 0.84 | MAPK1 (0.46) | USP7TP53TDP1LMNAMAPK1 | |
| SCHEMBL7014196 | 0.83 | MAPK1 (0.46) | USP7MAPTTP53TDP1LMNA | |
| SCHEMBL7019301 | 0.74 | TP53 (0.45) | MAPTTP53TDP1MAPK1ALDH1A1 | |
| SCHEMBL7020184 | 0.74 | TP53 (0.44) | HPGDPOLBMAPTTP53TDP1 | |
| SCHEMBL7018715 | 0.73 | TP53 (0.48) | MAPTTP53TDP1LMNAMAPK1 | |
| SCHEMBL7015123 | 0.73 | LMNA (0.66) | POLBTP53LMNAMAPK1KMT2A | |
| SCHEMBL7017888 | 0.72 | TP53 (0.47) | MAPTTP53TDP1LMNAMAPK1 | |
| SCHEMBL7008873 | 0.71 | TP53 (0.42) | HPGDPOLBMAPTTP53TDP1 | |
| SCHEMBL7019303 | 0.71 | TP53 (0.46) | MAPTTP53TDP1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733633-B1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0733633-A1 | Heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-25 | — | — | EP | disclosed |