Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.52 |
| ▸ | DPP4 | P27487 | 3/20 | 0.44 |
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | CTSV | O60911 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4452668 | 0.92 | CTSK (0.62) | CTSKCTSSCTSVCTSL | |
| SCHEMBL4452707 | 0.90 | CTSK (0.50) | CTSKDPP4CTSSCTSVCTSL | |
| SCHEMBL4451932 | 0.90 | CTSK (0.47) | CTSKCTSSCTSVCTSLCHRM4 | |
| SCHEMBL4452660 | 0.89 | CTSK (0.49) | CTSKCTSSCTSVCTSL | |
| SCHEMBL4452610 | 0.89 | CTSK (0.49) | CTSKCTSSCTSVCTSL | |
| SCHEMBL4451610 | 0.89 | CTSS (0.55) | CTSKDPP4CTSSCTSVCTSL | |
| SCHEMBL4459438 | 0.88 | CTSK (0.48) | CTSKDPP4CTSSCTSVCTSL | |
| SCHEMBL7015308 | 0.87 | CTSK (0.46) | CTSKCTSSCTSVCTSL | |
| SCHEMBL4458891 | 0.87 | CTSK (0.49) | CTSKCTSSCTSVCTSLNAMPT | |
| SCHEMBL4451291 | 0.87 | CTSK (0.56) | CTSKDPP4CTSSCTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |