Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421082 | 0.82 | ALDH1A1 (0.43) | TYMPALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL29874641 | 0.79 | HKDC1 (0.49) | TYMPALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL28254837 | 0.77 | SOS1 (0.45) | TYMPALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL338172 | 0.77 | CES1 (0.55) | TYMPALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL30125426 | 0.76 | DNMT1 (0.50) | TYMPALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL369327 | 0.76 | DNMT1 (0.50) | TYMPALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL27110927 | 0.75 | CYP2A6 (0.46) | ALDH1A1HSD17B10HIF1ACYP1B1CYP1A2 | |
| SCHEMBL26191589 | 0.75 | CYP2A6 (0.52) | TYMPALDH1A1HSD17B10CYP1A2CYP2A6 | |
| SCHEMBL21549260 | 0.74 | ALDH1A1 (0.44) | ALDH1A1HSD17B10HIF1ACYP1B1CYP1A2 | |
| SCHEMBL7243627 | 0.74 | CES1 (0.52) | TYMPALDH1A1HSD17B10HIF1ACYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775115-B1 | DIMERIC ARYLISOQUINOLINE ALKALOIDS AND SYNTHESIS METHODS THEREOF | US HEALTH (US) | 2003-01-22 | — | — | EP | disclosed |
| US-5786482-A | Dimeric arylisoquinoline alkaloids and synthesis method thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-07-28 | — | — | US | disclosed |
| EP-0775115-A1 | DIMERIC ARYLISOQUINOLINE ALKALOIDS AND SYNTHESIS METHODS THEREOF | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) | 1997-05-28 | — | — | EP | disclosed |
| US-5578729-A | Dimeric arylisoquinoline alkaloid compounds | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-11-26 | — | — | US | disclosed |
| WO-1996003381-A1 | DIMERIC ARYLISOQUINOLINE ALKALOIDS AND SYNTHESIS METHODS THEREOF | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-02-08 | — | — | WO | disclosed |