Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 9/20 | 0.43 |
| ▸ | TCF7L2 | Q9NQB0 | 9/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7009771 | 0.94 | PDE5A (0.50) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL8185831 | 0.90 | MAPT (0.48) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7022055 | 0.90 | SMN1; SMN2 (0.49) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7010973 | 0.89 | MAPT (0.44) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7013924 | 0.87 | MAPT (0.45) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7015052 | 0.86 | PDE4A (0.50) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7015240 | 0.86 | PDE4A (0.45) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL8170167 | 0.85 | SMN1; SMN2 (0.48) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7017130 | 0.85 | PDE5A (0.46) | KMT2AMEN1MAPTHTTSMN1; SMN2 | |
| SCHEMBL7014043 | 0.85 | RNASEL (0.41) | KMT2AMEN1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934321-B1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 2003-08-06 | — | — | EP | disclosed |
| EP-0934321-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017668-A1 | THIENOPYRIMIDINE WITH PHOSPHODIESTERASE V INHIBITING EFFECT | MERCK PATENT GMBH (DE) | 1998-04-30 | — | — | WO | disclosed |