Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.45 |
| ▸ | USP5 | P45974 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 3/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014329 | 0.90 | COMT (0.44) | COMTUSP5CCR5PRCPDRD2 | |
| SCHEMBL942368 | 0.72 | MMP3 (0.46) | COMTUSP5PRCPDRD2RAB9A | |
| SCHEMBL12911295 | 0.71 | MMP3 (0.52) | COMTUSP5CCR5DRD2CCR1 | |
| SCHEMBL7131238 | 0.71 | DRD2 (0.41) | DRD2MAPTALDH1A1 | |
| SCHEMBL940834 | 0.70 | MMP3 (0.44) | COMTUSP5PRCPDRD2RAB9A | |
| SCHEMBL6808427 | 0.69 | MMP3 (0.41) | COMTUSP5DRD2MMP3 | |
| SCHEMBL7015188 | 0.67 | USP5 (0.41) | COMTUSP5CCR5CCR1RAB9A | |
| SCHEMBL942270 | 0.66 | DPP4 (0.49) | COMTUSP5CCR5ALDH1A1SMN1; SMN2 | |
| SCHEMBL4698592 | 0.66 | USP5 (0.50) | COMTUSP5CCR5DRD2CCR1 | |
| SCHEMBL7037798 | 0.66 | USP5 (0.47) | USP5CCR5DRD2CCR1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| EP-1370556-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074767-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |