Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017112 | 0.89 | MMP2 (0.42) | USP5SMN1; SMN2CCR1 | |
| SCHEMBL941517 | 0.70 | MMP3 (0.45) | USP5NAMPTFAAHSMN1; SMN2PKM | |
| SCHEMBL12911295 | 0.70 | MMP3 (0.52) | USP5NAMPTSMN1; SMN2CCR1PKM | |
| SCHEMBL942270 | 0.70 | DPP4 (0.49) | USP5NAMPTSMN1; SMN2CCR5COMT | |
| SCHEMBL4698592 | 0.70 | USP5 (0.50) | USP5NAMPTFAAHCCR1CCR5 | |
| SCHEMBL7020098 | 0.69 | MMP1 (0.53) | NAMPT | |
| SCHEMBL4698427 | 0.68 | USP5 (0.48) | USP5NAMPTCCR1CCR5NPC1 | |
| SCHEMBL7014329 | 0.68 | COMT (0.44) | USP5NAMPTSMN1; SMN2CCR1CCR5 | |
| SCHEMBL6265718 | 0.68 | FAAH (0.41) | FAAHSMN1; SMN2SLC6A9 | |
| SCHEMBL10460507 | 0.67 | QDPR (0.62) | FAAHCCR1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |