Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.57 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.57 |
| ▸ | PPARG | P37231 | 2/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.57 |
| ▸ | NAE1 | Q13564 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9090817 | 0.93 | AGTR1 (0.51) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL12476143 | 0.89 | AGTR2 (0.58) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL7018921 | 0.89 | AGTR2 (0.58) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL12527631 | 0.88 | AGTR2 (0.57) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL13465074 | 0.88 | AGTR2 (0.59) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL3977106 | 0.88 | AGTR2 (0.62) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL17998734 | 0.86 | AGTR2 (0.57) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL30951658 | 0.86 | AGTR2 (0.52) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL30206864 | 0.86 | PPARG (0.59) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL7018017 | 0.86 | PPARG (0.59) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233955-B2 | Process for the preparation of azilsartan medoxomil | JUBILANT LIFE SCIENCES, LTD. (IN) | 2016-01-12 | — | — | US | disclosed |
| US-9233955-B2 | Process for the preparation of azilsartan medoxomil | JUBILANT LIFE SCIENCES, LTD. (IN) | 2016-01-12 | — | — | US | disclosed |
| WO-2012157977-A2 | MANUFACTURING METHOD OF HETEROCYCLIC COMPOUND | HANMI FINE CHEMICAL CO., LTD. (KR) | 2012-11-22 | — | — | WO | disclosed |
| EP-0520423-B1 | Heterocyclic compounds, their production and use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-14 | — | — | EP | disclosed |
| US-6100252-A | SPECIFIED COMPOUNDS INCLUDING METHYL 2-BUTYL-1-((2'-(2-OXO-3H-1,2,3,5-OXATHIADIAZOL-4-YL)BIPHENYL) METHYL)-BENZIMIDAZOLE-7-CARBOXYLATE; USE TO TREAT CIRCULATORY DISEASES SUCH AS HYPERTENSIVE DISEASES AND HEART DISEASES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-08-08 | — | — | US | disclosed |
| US-5354766-A | 2-Ethoxy-1-((2'(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl) biphenyl-4-yl)methyl)benzimidazole-7-carboxylic acid; hypotensive agents; CNS activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-10-11 | — | — | US | disclosed |
| US-5243054-A | Hypotensive agents, cardiovascular disorders or nervous system disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-07 | — | — | US | disclosed |
| EP-0520423-A2 | Heterocyclic compounds, their production and use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-30 | — | — | EP | disclosed |