Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | GAA | P10253 | 7/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HAT1 | O14929 | 2/20 | 0.42 |
| ▸ | EP300 | Q09472 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020296 | 0.87 | MAPT (0.57) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL6238938 | 0.85 | KMT2A (0.56) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL6431684 | 0.85 | MAPT (0.52) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL7052320 | 0.83 | PTPN5 (0.55) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL7634269 | 0.81 | ALDH1A1 (0.49) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL7012169 | 0.79 | ALDH1A1 (0.47) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL7191192 | 0.76 | ALDH1A1 (0.60) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL6218489 | 0.75 | HPGD (0.65) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL6247549 | 0.75 | MAPT (0.57) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL31160880 | 0.74 | KDM4E (0.45) | ALDH1A1HSD17B10KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | claimed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |