Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020296 | 0.90 | MAPT (0.57) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL7634269 | 0.89 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL6431684 | 0.88 | MAPT (0.52) | ALDH1A1GAAHSD17B10KDM4EHPGD | |
| SCHEMBL7012169 | 0.86 | ALDH1A1 (0.47) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL7019254 | 0.85 | ALDH1A1 (0.48) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL7052320 | 0.85 | PTPN5 (0.55) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL7620889 | 0.79 | HPGD (0.47) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL4252528 | 0.79 | CACNA1G (0.63) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL7191192 | 0.78 | ALDH1A1 (0.60) | KMT2AMEN1ALDH1A1GAAHSD17B10 | |
| SCHEMBL6218489 | 0.78 | HPGD (0.65) | KMT2AMEN1ALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531904-A1 | COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB | Warner-Lambert Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004007024-A1 | COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |