Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484204 | 0.80 | MAPT (0.33) | CA12CA1CA2CA9MAPT | |
| SCHEMBL15473432 | 0.67 | PARP10 (0.44) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL7019650 | 0.65 | TSHR (0.33) | TSHRCYP3A4 | |
| SCHEMBL12016683 | 0.63 | PARP10 (0.44) | CA12CA1CA2CA9GSK3B | |
| SCHEMBL12066538 | 0.59 | CA12 (0.34) | CA12CA1CA2CA9POLB | |
| SCHEMBL7859333 | 0.59 | PARP10 (0.61) | ALDH1A1KDM4EMAPTPARP10PARP11 | |
| SCHEMBL16602943 | 0.58 | — | — | |
| SCHEMBL10989615 | 0.58 | ALDH1A1 (0.54) | POLBALDH1A1KDM4EMAPTPARP10 | |
| SCHEMBL11189916 | 0.57 | TSHR (0.72) | ALDH1A1KDM4EMAPTTSHRCYP3A4 | |
| SCHEMBL15473430 | 0.57 | PARP10 (0.44) | CA1CA2CA9POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705832-B1 | Serotonergic modulators | LILLY CO ELI (GB) | 2003-08-13 | — | — | EP | disclosed |
| US-5563147-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0705832-A1 | Serotonergic modulators | LILLY INDUSTRIES LIMITED (GB) | 1996-04-10 | — | — | EP | disclosed |