Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 15/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019899 | 1.00 | XDH (0.42) | XDHLMNAMAPTALDH1A1HPGD | |
| SCHEMBL7015566 | 0.87 | XDH (0.44) | XDHLMNAMAPTALDH1A1HPGD | |
| SCHEMBL7015562 | 0.87 | XDH (0.44) | XDHLMNAMAPTALDH1A1HPGD | |
| SCHEMBL7022645 | 0.78 | QPCT (0.32) | ALDH1A1 | |
| SCHEMBL7022644 | 0.78 | QPCT (0.32) | ALDH1A1 | |
| SCHEMBL7016851 | 0.75 | ADORA2A (0.33) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7022754 | 0.75 | ADORA3 (0.36) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7016847 | 0.75 | ADORA2A (0.33) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7022760 | 0.75 | ADORA3 (0.36) | ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7022638 | 0.74 | XDH (0.41) | XDHLMNAMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |